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Discerning mechanistically rewired biological pathways by cumulative interaction heterogeneity statistics

Changes in response of a biological pathway could be a consequence of either pathway rewiring, changed input, or a combination of both. Most pathway analysis methods are not designed for mechanistic rewiring such as regulatory element variations. This limits our understanding of biological pathway e...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cotton, Travis B., Nguyen, Hien H., Said, Joseph I., Ouyang, Zhengyu, Zhang, Jinfa, Song, Mingzhou
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894439/
https://ncbi.nlm.nih.gov/pubmed/25921728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09634
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