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Efficient Determination of Free Energy Landscapes in Multiple Dimensions from Biased Umbrella Sampling Simulations Using Linear Regression

[Image: see text] The weighted histogram analysis method (WHAM) is a standard protocol for postprocessing the information from biased umbrella sampling simulations to construct the potential of mean force with respect to a set of order parameters. By virtue of the WHAM equations, the unbiased densit...

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Publicat a:J Chem Theory Comput
Autors principals: Meng, Yilin, Roux, Benoît
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894281/
https://ncbi.nlm.nih.gov/pubmed/26574437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct501130r
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