Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth

Dll4, one of the Notch ligands, is overexpressed in ovarian cancer, especially in tumors resistant to anti–VEGF therapy. Here, we examined the biological effects of dual anti-Dll4 and anti-VEGF therapy in ovarian cancer models. Using Dll4-Fc blockade and anti-Dll4 antibodies (murine REGN1035 and hum...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Huang, Jie, Hu, Wei, Hu, Limin, Previs, Rebecca A., Dalton, Heather J., Yang, Xiao-Yun, Sun, Yunjie, McGuire, Michael, Rupaimoole, Rajesha, Nagaraja, Archana S, Kang, Yu, Liu, Tao, Nick, Alpa M., Jennings, Nicholas B., Coleman, Robert L., Jaffe, Robert B., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893925/
https://ncbi.nlm.nih.gov/pubmed/27009216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0144
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