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Protocol of a randomised phase III clinical trial of sequential capecitabine or 5-fluorouracil plus bevacizumab (Cape/5-FU-Bmab) to capecitabine or 5-fluorouracil plus oxaliplatin plus bevacizumab (CapeOX/mFOLFOX6-Bmab) versus combination CapeOX/mFOLFOX6-Bmab in advanced colorectal cancer: the C-cubed (C(3)) study

INTRODUCTION: Results from several randomised trials suggest that the sequential use of cytotoxic agents in patients with metastatic colorectal cancer (mCRC) has the potential to improve overall survival compared with combination chemotherapy. This study is designed to investigate whether sequential...

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Bibliographische Detailangaben
Veröffentlicht in:BMJ Open
Hauptverfasser: Nagasaka, Takeshi, Mishima, Hideyuki, Sawaki, Akira, Shimokawa, Mototsugu, Inukai, Michio, Shinozaki, Katsunori, Tanioka, Hiroaki, Nasu, Junichiro, Nishina, Tomohiro, Hazama, Shoichi, Okajima, Masazumi, Yamaguchi, Yoshiyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893850/
https://ncbi.nlm.nih.gov/pubmed/27256093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-011454
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