S-1 and irinotecan plus bevacizumab versus mFOLFOX6 or CapeOX plus bevacizumab as first-line treatment in patients with metastatic colorectal cancer (TRICOLORE): a randomized, open-label, phase III, noninferiority trial

BACKGROUND: Combination therapy with oral fluoropyrimidine and irinotecan has not yet been established as first-line treatment of metastatic colorectal cancer (mCRC). We carried out a randomized, open-label, phase III trial to determine whether S-1 and irinotecan plus bevacizumab is noninferior to m...

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Bibliografiske detaljer
Udgivet i:Ann Oncol
Main Authors: Yamada, Y, Denda, T, Gamoh, M, Iwanaga, I, Yuki, S, Shimodaira, H, Nakamura, M, Yamaguchi, T, Ohori, H, Kobayashi, K, Tsuda, M, Kobayashi, Y, Miyamoto, Y, Kotake, M, Shimada, K, Sato, A, Morita, S, Takahashi, S, Komatsu, Y, Ishioka, C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889030/
https://ncbi.nlm.nih.gov/pubmed/29293874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx816
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