Protocol of a randomised phase III clinical trial of sequential capecitabine or 5-fluorouracil plus bevacizumab (Cape/5-FU-Bmab) to capecitabine or 5-fluorouracil plus oxaliplatin plus bevacizumab (CapeOX/mFOLFOX6-Bmab) versus combination CapeOX/mFOLFOX6-Bmab in advanced colorectal cancer: the C-cubed (C(3)) study

INTRODUCTION: Results from several randomised trials suggest that the sequential use of cytotoxic agents in patients with metastatic colorectal cancer (mCRC) has the potential to improve overall survival compared with combination chemotherapy. This study is designed to investigate whether sequential...

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Bibliografische gegevens
Gepubliceerd in:BMJ Open
Hoofdauteurs: Nagasaka, Takeshi, Mishima, Hideyuki, Sawaki, Akira, Shimokawa, Mototsugu, Inukai, Michio, Shinozaki, Katsunori, Tanioka, Hiroaki, Nasu, Junichiro, Nishina, Tomohiro, Hazama, Shoichi, Okajima, Masazumi, Yamaguchi, Yoshiyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2016
Onderwerpen:
Gastroenterology and Hepatology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893850/
https://ncbi.nlm.nih.gov/pubmed/27256093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-011454
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