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Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway

Both adaptive and acquired resistance significantly limits the efficacy of the epidermal growth factor receptor (EGFR) kinase inhibitors. However, the distinct or common mechanisms of adaptive and acquired resistance have not been fully characterized. Here, through systematic modeling of erlotinib r...

詳細記述

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書誌詳細
出版年:Theranostics
主要な著者: Ma, Pengfei, Fu, Yujie, Chen, Minjiang, Jing, Ying, Wu, Jie, Li, Ke, Shen, Ying, Gao, Jian-Xin, Wang, Mengzhao, Zhao, Xiaojing, Zhuang, Guanglei
フォーマット: Artigo
言語:Inglês
出版事項: Ivyspring International Publisher 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893648/
https://ncbi.nlm.nih.gov/pubmed/27279914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.14409
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