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Functional Assay for BRCA1: Mutagenesis of C-Terminal Region Reveals Critical Residues for Transcription Activation
The breast and ovarian cancer susceptibility gene product BRCA1 is a tumor suppressor but its precise biochemical function remains unknown. The BRCA1 C-terminus acts as a transcription activation domain and germ-line cancer-predisposing mutations in this region abolish transcription activation where...
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| Vydáno v: | Cancer Res |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2000
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4893312/ https://ncbi.nlm.nih.gov/pubmed/10811118 |
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