FUNCTIONAL ANALYSIS OF BRCA1 C-TERMINAL MISSENSE MUTATIONS IDENTIFIED IN BREAST AND OVARIAN CANCER FAMILIES

Germ line mutations in the breast and ovarian cancer susceptibility gene BRCA1 are responsible for the majority of cases involving hereditary breast and ovarian cancer. While all truncating mutations are considered as functionally deleterious, most of the missense variants identified to date cannot...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Vallon-Christersson, Johan, Cayanan, Charmagne, Haraldsson, Karin, Loman, Niklas, Bergthorsson, Jon Thor, Brøndum-Nielsen, Karen, Gerdes, Anne-Marie, Møller, Pål, Kristoffersson, Ulf, Olsson, Håkan, Borg, Åke, Monteiro, Alvaro N.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756649/
https://ncbi.nlm.nih.gov/pubmed/11157798
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