Phase 1 Study of ABT‐751 in Combination With CAPIRI (Capecitabine and Irinotecan) and Bevacizumab in Patients With Advanced Colorectal Cancer

ABT‐751 is an orally bioavailable sulfonamide with antimitotic properties. A nonrandomized phase 1 dose‐escalation study of ABT‐751 in combination with CAPIRI (capecitabine and irinotecan) and bevacizumab was conducted to define the maximum tolerated dose, dose‐limiting toxicity (DLT), and pharmacok...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Pharmacol
Main Authors: Rudek, Michelle A., Dasari, Arvind, Laheru, Daniel, He, Ping, Jin, Runyan, Walker, Rosalind, Taylor, Gretchen E., Jimeno, Antonio, Donehower, Ross C., Hidalgo, Manuel, Messersmith, Wells A., Purcell, W. Thomas
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892995/
https://ncbi.nlm.nih.gov/pubmed/26632033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.681
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki