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THE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS
We propose a dose-finding design for Phase I oncology trials where each new patient is assigned to the dose most likely to be the target dose given observed data. The main model assumption is that the dose-toxicity curve is non-decreasing. This method is beneficial when it is desirable to assign a p...
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| Publicado en: | Stat Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4892992/ https://ncbi.nlm.nih.gov/pubmed/26833922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6886 |
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