Delivery of Cas9 protein into mouse zygotes through a series of electroporation dramatically increased the efficiency of model creation

Previously we established Zygote Electroporation of Nucleases (ZEN) technology as an efficient and high-throughput way to generate genetically modified mouse models. However, there were significant variations of the targeting efficiency among different genomic loci using our previously published pro...

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Detalles Bibliográficos
Publicado en:J Genet Genomics
Autores principales: Wang, Wenbo, Kutny, Peter M., Byers, Shannon L., Longstaff, Charles J., DaCosta, Michael J., Pang, Changhong, Zhang, Yingfan, Taft, Robert A., Buaas, Frank W., Wang, Haoyi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892940/
https://ncbi.nlm.nih.gov/pubmed/27210041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgg.2016.02.004
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