κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain

Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). How...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Weems, Peyton W., Witty, Christine F., Amstalden, Marcel, Coolen, Lique M., Goodman, Robert L., Lehman, Michael N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891780/
https://ncbi.nlm.nih.gov/pubmed/27064940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1763
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