The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

The endothelial protein C receptor (EPCR) appears to play an important role in Plasmodium falciparum endothelial cell binding in severe malaria (SM). Despite consistent findings of elevated soluble EPCR (sEPCR) in other infectious diseases, field studies to date have provided conflicting data about...

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Publicado no:Sci Rep
Main Authors: Shabani, Estela, Opoka, Robert O., Bangirana, Paul, Park, Gregory S., Vercellotti, Gregory M., Guan, Weihua, Hodges, James S., Lavstsen, Thomas, John, Chandy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891778/
https://ncbi.nlm.nih.gov/pubmed/27255786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27084
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