Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria

BACKGROUND: Cerebral malaria (CM) is characterized by the sequestration of Plasmodium-infected erythrocytes (pRBCs) to host brain microvasculature beds via P. falciparum erythrocyte membrane protein 1 (PfEMP1). Under normal conditions, activated protein C (APC) bound to endothelial protein C recepto...

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Bibliographic Details
Published in:Front Genet
Main Authors: Cespedes, Juan Carlos, Hibbert, Jacqueline, Krishna, Sri, Yan, Fengxia, Bharti, Praveen K., Stiles, Jonathan K., Liu, Mingli
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050639/
https://ncbi.nlm.nih.gov/pubmed/32153634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00056
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