T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies

T cells expressing chimeric antigen receptors (CARs) or the infusion of bispecific T-cell engagers (BITEs) have shown antitumor activity in humans for CD19-positive malignancies. While BITEs redirect the large reservoir of resident T cells to tumors, CAR T cells rely on significant in vivo expansion...

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Pubblicato in:Sci Rep
Autori principali: Velasquez, Mireya Paulina, Torres, David, Iwahori, Kota, Kakarla, Sunitha, Arber, Caroline, Rodriguez-Cruz, Tania, Szoor, Arpad, Bonifant, Challice L., Gerken, Claudia, Cooper, Laurence J. N., Song, Xiao-Tong, Gottschalk, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891739/
https://ncbi.nlm.nih.gov/pubmed/27255991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27130
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