Context-dependent effects of cellular senescence in cancer development

Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via th...

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Udgivet i:Br J Cancer
Main Authors: Lecot, Pacome, Alimirah, Fatouma, Desprez, Pierre-Yves, Campisi, Judith, Wiley, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891501/
https://ncbi.nlm.nih.gov/pubmed/27140310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.115
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