Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer

PURPOSE: The PI3K/Akt/mTOR pathway is activated in most castration-resistant prostate cancer (CRPC). Transcriptionally active androgen receptor (AR) plays a role in the majority of CRPC. Therefore, co-targeting full-length (FL) AR and PI3K/Akt/mTOR signaling has been proposed as a possible more effe...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Kato, Minoru, Banuelos, Carmen A., Imamura, Yusuke, Leung, Jacky K., Caley, Daniel P., Wang, Jun, Mawji, Nasrin R., Sadar, Marianne D.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891302/
https://ncbi.nlm.nih.gov/pubmed/26712685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2119
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