Efficient pDNA Delivery Using Cationic 2-Hydroxypropyl-β-Cyclodextrin Pluronic Based Polyrotaxanes()

A family of Pluronic-based, cholesterol end-capped cationic polyrotaxanes (PR(+)), threaded with 2-hydroxypropyl-β-cyclodextrin (HPCD), was synthesized for efficient and low toxicity plasmid DNA (pDNA) delivery into multiple cell lines. All PR(+) formed highly stable, positively charged complexes wi...

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Bibliographic Details
Published in:Macromol Biosci
Main Authors: Badwaik, Vivek, Mondjinou, Yawo, Kulkarni, Aditya, Liu, Linjia, Demoret, Asher, Thompson, David H.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891183/
https://ncbi.nlm.nih.gov/pubmed/26257319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.201500220
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