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Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

Statins (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors) are well-established agents to treat hyperlipidemic states. Experimental and epidemiological evidence further implies an anticancer effect of these substances. This study investigates the mechanism underlying human lung c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Walther, Udo, Emmrich, Kristin, Ramer, Robert, Mittag, Nadine, Hinz, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891124/
https://ncbi.nlm.nih.gov/pubmed/26863638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7213
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