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Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Among different structurally related COX-2 inhibitors, only celecoxib was found to cause apoptosis and cell death of human lung cancer cells (IC(50) values of 19.96 µM [A549], 12....

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Main Authors: Ramer, Robert, Walther, Udo, Borchert, Philipp, Laufer, Stefan, Linnebacher, Michael, Hinz, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793616/
https://ncbi.nlm.nih.gov/pubmed/23943857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042283
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