PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be “synthetic lethal” in cancers deficient in BRCA...

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Foilsithe in:Oncotarget
Main Authors: Wurster, Stephanie, Hennes, Fabian, Parplys, Ann C., Seelbach, Jasna I., Mansour, Wael Y., Zielinski, Alexandra, Petersen, Cordula, Clauditz, Till S., Münscher, Adrian, Friedl, Anna A., Borgmann, Kerstin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891080/
https://ncbi.nlm.nih.gov/pubmed/26799421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6947
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