High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

In response to replication stress ATR signaling through CHK1 controls the intra-S checkpoint and is required for the maintenance of genomic integrity. Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double strand breaks and interstrand cro...

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Bibliografski detalji
Izdano u:Cell Cycle
Glavni autori: Parplys, Ann Christin, Seelbach, Jasna Irena, Becker, Saskia, Behr, Matthias, Wrona, Agnieszka, Jend, Camilla, Mansour, Wael Yassin, Joosse, Simon Andreas, Stuerzbecher, Horst-Werner, Pospiech, Helmut, Petersen, Cordula, Dikomey, Ekkehard, Borgmann, Kerstin
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825602/
https://ncbi.nlm.nih.gov/pubmed/26317153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1055996
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