Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Chromosomal instability not only has a negative effect on survival in triple-negative breast cancer, but also on the well treatable subgroup of luminal A tumors. This suggests a general mechanism independent of subtypes. Increased chromosomal instability (CIN) in triple-negative breast cancer (TNBC)...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Meyer, Felix, Becker, Saskia, Classen, Sandra, Parplys, Ann Christin, Mansour, Wael Yassin, Riepen, Britta, Timm, Sara, Ruebe, Claudia, Jasin, Maria, Wikman, Harriet, Petersen, Cordula, Rothkamm, Kai, Borgmann, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017274/
https://ncbi.nlm.nih.gov/pubmed/31963582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9010238
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