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PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be “synthetic lethal” in cancers deficient in BRCA...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Oncotarget |
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Κύριοι συγγραφείς: | , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Impact Journals LLC
2016
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891080/ https://ncbi.nlm.nih.gov/pubmed/26799421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6947 |
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