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Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling
Tumor initiating cells (TICs) serve as the root of tumor growth. After identifying TICs in spontaneous breast tumors of the MMTV-Wnt1 mouse model, we confirmed the specific expression and activation of Yes-associated protein 1 (Yap1) within TICs. To investigate the role of Yap1 in the self-renewal o...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891077/ https://ncbi.nlm.nih.gov/pubmed/26695440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6655 |
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