Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens

Aromatic amines (AAs) are chemicals of industrial, pharmacological and environmental relevance. Certain AAs, such as 4-aminobiphenyl (4-ABP), are human carcinogens that require enzymatic metabolic activation to reactive chemicals to form genotoxic DNA adducts. Arylamine N-acetyltransferases (NAT) ar...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Duval, Romain, Xu, Ximing, Bui, Linh-Chi, Mathieu, Cécile, Petit, Emile, Cariou, Kevin, Dodd, Robert H., Dupret, Jean-Marie, Rodrigues-Lima, Fernando
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890997/
https://ncbi.nlm.nih.gov/pubmed/26840026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7086
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