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Generation of Multiple Reporter Ions from a Single Isobaric Reagent Increases Multiplexing Capacity for Quantitative Proteomics

Isobaric labeling strategies for mass spectrometry-based proteomics enable multiplexed simultaneous quantification of samples and therefore substantially increase the sample throughput in proteomics. However, despite these benefits, current limits to multiplexing capacity are prohibitive for large s...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Braun, Craig R., Bird, Gregory H., Wuhr, Martin, Erickson, Brian K., Rad, Ramin, Walensky, Loren D., Gygi, Steven P., Haas, Wilhelm
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890644/
https://ncbi.nlm.nih.gov/pubmed/26308379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b02307
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