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A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer
Although human LINE-1 (L1) elements are actively mobilized in many cancers, a role for somatic L1 retrotransposition in tumor initiation has not been conclusively demonstrated. Here, we identify a novel somatic L1 insertion in the APC tumor suppressor gene that provided us with a unique opportunity...
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| Veröffentlicht in: | Genome Res |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889970/ https://ncbi.nlm.nih.gov/pubmed/27197217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.201814.115 |
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