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Engineering a ribozyme cleavage-induced split fluorescent aptamer complementation assay
Hammerhead ribozymes are self-cleaving RNA molecules capable of regulating gene expression in living cells. Their cleavage performance is strongly influenced by intra-molecular loop–loop interactions, a feature not readily accessible through modern prediction algorithms. Ribozyme engineering and eff...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889925/ https://ncbi.nlm.nih.gov/pubmed/26939886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw117 |
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