Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease

Background. Elevated brain iron levels have been implicated in the pathogenesis of Parkinson's disease (PD). However, the precise mechanism underlying abnormal iron accumulation in PD is not clear. Hepcidin, a hormone primarily produced by hepatocytes, acts as a key regulator in both systemic a...

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Bibliographic Details
Published in:Parkinsons Dis
Main Authors: Xu, Qi, Kanthasamy, Anumantha G., Jin, Huajun, Reddy, Manju B.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889865/
https://ncbi.nlm.nih.gov/pubmed/27298749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8684130
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