The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced t...

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Bibliographic Details
Published in:Nat Neurosci
Main Authors: Ren, Wenjie, Centeno, Maria Virginia, Berger, Sara, Wu, Ying, Na, Xiaodong, Liu, Xianguo, Kondapalli, Jyothisri, Apkarian, A Vania, Martina, Marco, Surmeier, D James
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889808/
https://ncbi.nlm.nih.gov/pubmed/26691834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4199
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