The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced t...

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Pubblicato in:Nat Neurosci
Autori principali: Ren, Wenjie, Centeno, Maria Virginia, Berger, Sara, Wu, Ying, Na, Xiaodong, Liu, Xianguo, Kondapalli, Jyothisri, Apkarian, A Vania, Martina, Marco, Surmeier, D James
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889808/
https://ncbi.nlm.nih.gov/pubmed/26691834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4199
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