The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced t...

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Publicat a:Nat Neurosci
Autors principals: Ren, Wenjie, Centeno, Maria Virginia, Berger, Sara, Wu, Ying, Na, Xiaodong, Liu, Xianguo, Kondapalli, Jyothisri, Apkarian, A Vania, Martina, Marco, Surmeier, D James
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889808/
https://ncbi.nlm.nih.gov/pubmed/26691834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4199
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