Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras

Chronic and juvenile myelomonocytic leukemias (CMML and JMML) are myelodysplastic/myeloproliferative neoplasia (MDS/MPN) overlap syndromes that respond poorly to conventional treatments. Aberrant Ras activation due to NRAS, KRAS, PTPN11, CBL, and NF1 mutations is common in CMML and JMML. However, no...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Leukemia
मुख्य लेखकों: Akutagawa, Jon, Huang, Tannie Q., Epstein, Inbal, Chang, Tiffany, Quirindongo-Crespo, Maricel, Cottonham, Charisa L., Dail, Monique, Slusher, Barbara S., Friedman, Lori S., Sampath, Deepak, Braun, Benjamin S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889473/
https://ncbi.nlm.nih.gov/pubmed/26965285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.14
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