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Discovery of a Small Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation
Sorely missing from the “toolkit” for directed differentiation of stem/progenitor cells are agonists of the BMP signaling pathway. Using a high throughput chemical screen, we discovered that PD407824, a checkpoint kinase 1 (CHK1) inhibitor, increases the sensitivity of cells to sub-threshold amounts...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889468/ https://ncbi.nlm.nih.gov/pubmed/27210748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.066 |
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