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Necroptosis-independent signaling by the RIP kinases in inflammation

Recent advances have identified a signaling cascade involving receptor interacting protein kinase 1 (RIPK1), RIPK3 and the pseudokinase mixed lineage kinase domain-like (MLKL) that is crucial for induction of necroptosis, a non-apoptotic form of cell death. RIPK1–RIPK3–MLKL-mediated necroptosis has...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Moriwaki, Kenta, Chan, Francis Ka-Ming
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889460/
https://ncbi.nlm.nih.gov/pubmed/27048814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2203-4
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