Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols

Cellular lipids are speculated to act as key intermediates in Hedgehog signal transduction, but their precise identity and function remain enigmatic. In an effort to identify such lipids, we pursued a Hedgehog pathway inhibitory activity that is particularly abundant in flagellar lipids of Chlamydom...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sever, Navdar, Mann, Randall K., Xu, Libin, Snell, William J., Hernandez-Lara, Carmen I., Porter, Ned A., Beachy, Philip A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889404/
https://ncbi.nlm.nih.gov/pubmed/27162362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604984113
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