NLRC5/MHC class I transactivator is a target for immune evasion in cancer

Cancer cells develop under immune surveillance, thus necessitating immune escape for successful growth. Loss of MHC class I expression provides a key immune evasion strategy in many cancers, although the molecular mechanisms remain elusive. MHC class I transactivator (CITA), known as “NLRC5” [NOD-li...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Yoshihama, Sayuri, Roszik, Jason, Downs, Isaac, Meissner, Torsten B., Vijayan, Saptha, Chapuy, Bjoern, Sidiq, Tabasum, Shipp, Margaret A., Lizee, Gregory A., Kobayashi, Koichi S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889388/
https://ncbi.nlm.nih.gov/pubmed/27162338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602069113
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