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High-speed atomic force microscopy reveals structural dynamics of amyloid β(1–42) aggregates

Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various neurodegenerative diseases. This process involves protein assembly into oligomeric intermediates and fibrils with highly polymorphic molecular structures. These structural differences may be responsible for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Watanabe-Nakayama, Takahiro, Ono, Kenjiro, Itami, Masahiro, Takahashi, Ryoichi, Teplow, David B., Yamada, Masahito
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889376/
https://ncbi.nlm.nih.gov/pubmed/27162352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524807113
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