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Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

Sphingolipids exhibit extreme functional and chemical diversity that is in part determined by their hydrophobic moiety, ceramide. In mammals, the fatty acyl chain length variation of ceramides is determined by six (dihydro)ceramide synthase (CerS) isoforms. Previously, we and others showed that muta...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Spassieva, Stefka D., Ji, Xiaojie, Liu, Ye, Gable, Kenneth, Bielawski, Jacek, Dunn, Teresa M., Bieberich, Erhard, Zhao, Lihong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889366/
https://ncbi.nlm.nih.gov/pubmed/27162368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522071113
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