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Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

Sphingolipids exhibit extreme functional and chemical diversity that is in part determined by their hydrophobic moiety, ceramide. In mammals, the fatty acyl chain length variation of ceramides is determined by six (dihydro)ceramide synthase (CerS) isoforms. Previously, we and others showed that muta...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Spassieva, Stefka D., Ji, Xiaojie, Liu, Ye, Gable, Kenneth, Bielawski, Jacek, Dunn, Teresa M., Bieberich, Erhard, Zhao, Lihong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889366/
https://ncbi.nlm.nih.gov/pubmed/27162368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522071113
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