Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

The primary sweet sensor in mammalian taste cells for sugars and noncaloric sweeteners is the heteromeric combination of type 1 taste receptors 2 and 3 (T1R2+T1R3, encoded by Tas1r2 and Tas1r3 genes). However, in the absence of T1R2+T1R3 (e.g., in Tas1r3 KO mice), animals still respond to sugars, ar...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sukumaran, Sunil K., Yee, Karen K., Iwata, Shusuke, Kotha, Ramana, Quezada-Calvillo, Roberto, Nichols, Buford L., Mohan, Sankar, Pinto, B. Mario, Shigemura, Noriatsu, Ninomiya, Yuzo, Margolskee, Robert F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889361/
https://ncbi.nlm.nih.gov/pubmed/27162343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520843113
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