Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon

Cereblon (CRBN), a substrate receptor for the cullin–RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs). Here we report that glutamine synthetase (GS) is an endogenous substrate of CRL4(CRBN). Upo...

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Publicado no:Mol Cell
Main Authors: Van Nguyen, Thang, Lee, J. Eugene, Sweredoski, Michael J., Yang, Seung-Joo, Jeon, Seung-Je, Harrison, Joseph S., Yim, Jung-Hyuk, Lee, Sang Ghil, Handa, Hiroshi, Kuhlman, Brian, Jeong, Ji-Seon, Reitsma, Justin M., Park, Chul-Seung, Hess, Sonja, Deshaies, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889030/
https://ncbi.nlm.nih.gov/pubmed/26990986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.032
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