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Genetic code expansion in stable cell lines enables encoded chromatin modification

Genetically encoded unnatural amino acids provide powerful strategies for modulating the molecular functions of proteins in mammalian cells. However this approach has not been coupled to genome-wide measurements, because efficient unnatural amino acid incorporation is limited to transient expression...

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Publicado en:Nat Methods
Main Authors: Elsässer, Simon J., Ernst, Russell J, Walker, Olivia S., Chin, Jason W.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888942/
https://ncbi.nlm.nih.gov/pubmed/26727110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3701
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