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The origin of the cooperativity in the streptavidin-biotin system: A computational investigation through molecular dynamics simulations
Previous experimental study measuring the binding affinities of biotin to the wild type streptavidin (WT) and three mutants (S45A, D128A and S45A/D128A double mutant) has shown that the loss of binding affinity from the double mutation is larger than the direct sum of those from two single mutations...
Tallennettuna:
| Julkaisussa: | Sci Rep |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4888747/ https://ncbi.nlm.nih.gov/pubmed/27249234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27190 |
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