HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha (HIF-1α) and 2 alpha (HIF-2α/EPAS1) are in the same family and act as master regulators of the adaptive response to hypoxia. HI...

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Publicat a:Sci Rep
Autors principals: Feng, Nan, Chen, Haiying, Fu, Sengwang, Bian, Zhaolian, Lin, Xiaolu, Yang, Li, Gao, Yunjie, Fang, Jingyuan, Ge, Zhizheng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888746/
https://ncbi.nlm.nih.gov/pubmed/27249651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27280
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