HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha (HIF-1α) and 2 alpha (HIF-2α/EPAS1) are in the same family and act as master regulators of the adaptive response to hypoxia. HI...

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Publicado no:Sci Rep
Main Authors: Feng, Nan, Chen, Haiying, Fu, Sengwang, Bian, Zhaolian, Lin, Xiaolu, Yang, Li, Gao, Yunjie, Fang, Jingyuan, Ge, Zhizheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888746/
https://ncbi.nlm.nih.gov/pubmed/27249651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27280
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