Antitumor effect of manumycin on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway

Manumycin is a natural, well-tolerated microbial metabolite and is regarded as a farnesyltransferase inhibitor. Some data suggest that manumycin inhibits proliferation of diverse cancer cells through various pathways. However, the antitumor effect of manumycin on colorectal cancer (CRC) remains unkn...

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Publicat a:Onco Targets Ther
Autors principals: Zhang, Jingyu, Jiang, Hua, Xie, Li, Hu, Jing, Li, Li, Yang, Mi, Cheng, Lei, Liu, Baorui, Qian, Xiaoping
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888730/
https://ncbi.nlm.nih.gov/pubmed/27307747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S102408
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