High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide

Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease (AD). We describe the engineering of cognate Anticalins as...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biochem J
Egile Nagusiak: Rauth, Sabine, Hinz, Dominik, Börger, Michael, Uhrig, Markus, Mayhaus, Manuel, Riemenschneider, Matthias, Skerra, Arne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Portland Press Ltd. 2016
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888463/
https://ncbi.nlm.nih.gov/pubmed/27029347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160114
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