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High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide
Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease (AD). We describe the engineering of cognate Anticalins as...
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| Udgivet i: | Biochem J |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4888463/ https://ncbi.nlm.nih.gov/pubmed/27029347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160114 |
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